# Nonspecific peripheral T cell lymphoma combined with pure red cell aplasia: a case report and literature review

## TL;DR

This paper reports a rare case of peripheral T cell lymphoma combined with pure red cell aplasia and describes the patient's response to treatment.

## Contribution

The novelty lies in the detailed clinical and pathological analysis of a rare co-occurrence of PTCL-NOS and PRCA.

## Key findings

- The patient showed significant improvement after ECHOP chemotherapy and maintenance treatment with lenalidomide.
- Bone marrow recovery and normalization of red blood cell production were observed.
- CD3+CD8+ T lymphocytes were no longer detectable post-treatment.

## Abstract

外周T细胞淋巴瘤非特指型（PTCL-NOS）合并纯红细胞再生障碍（PRCA）国内报道较少。本文报道1例PTCL-NOS患者，以重度贫血为首发表现，伴有多部位淋巴结肿大。实验室检查证实红细胞减少、网织红细胞比例降低、骨髓红细胞增生明显减低，骨髓CD3+CD8+ T淋巴细胞比例显著增高，淋巴结病理及免疫组化符合PTCL-NOS，TCRβ基因重排阳性，一线ECHOP方案化疗4个疗程后，患者肿大淋巴结显著缩小，全身CT评估部分缓解，血红蛋白升至正常，骨髓造血红系增生恢复正常，CD3+CD8+ T淋巴细胞未检出，目前口服来那度胺维持治疗，预后尚好。