# Evaluation of Radius Fracture Repair With Critical-Sized Bone Defects Using Polypropylene Surgical Mesh in Rats

## TL;DR

This study shows that using polypropylene surgical mesh improves bone healing in rats with large bone fractures, especially when combined with autologous grafts.

## Contribution

The novel contribution is demonstrating that polypropylene mesh enhances bone regeneration beyond autologous grafts alone in critical-sized defects.

## Key findings

- The graft + mesh group showed the most significant bone healing and callus formation after 6 weeks.
- Mesh scaffolds improved new bone formation, osteoblast and osteocyte counts, and bone microarchitecture.
- Mesh scaffolds offer superior osteogenic potential compared to grafts alone.

## Abstract

Bone fractures involving critical-sized defects pose a significant challenge in orthopedic surgery, often requiring innovative strategies to promote bone regeneration. This study aimed to evaluate the effectiveness of polypropylene surgical mesh in repairing critical-sized radius bone defects in a rat model. Treatments included autologous grafts and a combination of mesh and graft, compared with an untreated control group. After 6 weeks, X-ray and CT scan analyses revealed significant bone healing and callus formation in the treated groups, with the graft + mesh group showing the most pronounced improvement. Histomorphometric analyses demonstrated that the mesh scaffold significantly enhanced new bone formation, osteoblast and osteocyte counts, and bone microarchitecture compared with grafts alone. These findings suggest that mesh scaffolds offer superior osteogenic potential and could provide a promising adjunct for treating critical-sized bone defects. Future studies should explore optimized mesh designs and the interplay between osteogenesis and angiogenesis to improve clinical outcomes.