# A Randomized Crossover Trial Assessing Plaque Regrowth Dynamics in Adults With Use of an Oscillating‐Rotating Electric Toothbrush Versus a Manual Toothbrush Measured by Digital Plaque Image Analysis

**Authors:** Priscila Ferrari Peron, Ralf Adam, Julie Grender, Uta Mesples, Phyllis Hoke, Mike Rubush, Mary Kay Anastasia, Christina Erbe

PMC · DOI: 10.1002/cre2.70158 · Clinical and Experimental Dental Research · 2025-06-11

## TL;DR

This study found that an oscillating-rotating electric toothbrush reduces plaque regrowth more effectively than a manual toothbrush in adults.

## Contribution

The study provides empirical evidence on plaque regrowth dynamics using digital imaging analysis in a crossover trial.

## Key findings

- The O-R toothbrush showed significantly lower plaque levels compared to the manual brush at all time points.
- The O-R toothbrush reduced afternoon plaque by 21.2% and morning plaque by 23.5% overall.
- The benefit of the O-R toothbrush increased over time, with 28.1% lower plaque on Day 8.

## Abstract

This randomized crossover trial involving adult participants with ≥ 10% plaque coverage on anterior teeth compared dental plaque regrowth dynamics between an oscillating‐rotating (O‐R) electric toothbrush and a manual toothbrush using Digital Plaque Imaging Analysis.

Thirty‐four participants were randomized to one of 4 treatment sequences, each having four 8‐day treatment periods. Participants brushed twice daily with the assigned toothbrush. Morning and afternoon plaque were evaluated on Days 1, 3, and 8. The primary variable was afternoon percent plaque coverage, using repeated measures analysis from Days 1, 3, and 8.

The O‐R toothbrush produced lower mean plaque levels versus the manual toothbrush for all endpoints (p ≤ 0.001). The benefit for the O‐R toothbrush increased over time, demonstrating 16.4% (p = 0.001) and 28.1% (p < 0.001) lower afternoon plaque levels on Days 1 and 8, respectively, compared to the manual brush. Trends were similar for morning plaque. Repeated measures analyses showed a 21.2% reduction in overall afternoon plaque and a 23.5% reduction in overall morning plaque for the O‐R brush versus the manual brush (p < 0.001).

The O‐R toothbrush controlled plaque regrowth better than a manual toothbrush and should be considered to reduce plaque‐related diseases as part of a generalized prophylaxis and treatment plan.

ISRCTN Registry: ISRCTN 28649560.

## Full-text entities

- **Diseases:** plaque-related diseases (MESH:D003773)

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12156918/full.md

## References

38 references — full list in the complete paper: https://tomesphere.com/paper/PMC12156918/full.md

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Source: https://tomesphere.com/paper/PMC12156918