# Pain, Anger, and Rumination in Fibromyalgia: A Vicious Cycle?

**Authors:** Michael Tenti, Giorgia Varallo, Federica Cilenti, William Raffaeli, Maristella Scorza, Sandro Rubichi, Giada Pietrabissa, Gianluca Castelnuovo, Paola Gremigni, Giulia Casu

PMC · DOI: 10.3390/jcm14113662 · Journal of Clinical Medicine · 2025-05-23

## TL;DR

This study explores how pain, anger, and negative thinking in fibromyalgia patients form a harmful cycle that worsens their condition.

## Contribution

The study identifies a potential vicious cycle involving pain, metacognitions, anger rumination, and state anger in fibromyalgia patients.

## Key findings

- Pain intensity significantly affects negative beliefs and thought control in fibromyalgia patients.
- Pain intensity has a direct link to state anger, even after accounting for other factors.
- Interventions should target dysfunctional metacognitions and anger rumination to manage fibromyalgia.

## Abstract

Background/Objectives: Fibromyalgia is a debilitating syndrome characterized by persistent pain. Emerging evidence highlights the role of emotional and cognitive processes in modulating pain experience. Anger, for example, can influence pain and patients’ adjustment to the disease. Studies showed that metacognitions and anger rumination can worsen state anger, thereby increasing perceived pain intensity. The present study aims to investigate the presence of a relationship between pain, dysfunctional metacognitions, anger rumination, and state anger. Methods: The study included 446 participants who self-reported having a diagnosis of fibromyalgia confirmed by a rheumatologist or pain specialist. Participants completed self-report measures of metacognitions, anger rumination, state anger, and pain intensity. The serial mediation analysis was performed using Hayes’ PROCESS macro (Model 6). Results: Pain intensity showed a significant positive effect on negative beliefs about worry (β = 0.09; p < 0.05), need to control thoughts (β = 0.09; p < 0.05), and cognitive self-consciousness (β = 0.12; p < 0.05), but not on anger rumination. Across all serial mediation models, the direct effect of pain intensity on state anger remained significant even after controlling for the effect of mediators, indicating partial mediation. Conclusions: This study suggests a vicious cycle involving dysfunctional metacognitions, anger rumination, state anger, and pain intensity. Our findings also indicate a potential influence of pain on metacognitions and suggest a direct association between pain intensity and state anger. Interventions for anger management in fibromyalgia should consider dysfunctional metacognitions and anger rumination.

## Linked entities

- **Diseases:** fibromyalgia (MONDO:0005546)

## Full-text entities

- **Diseases:** Pain (MESH:D010146), Fibromyalgia (MESH:D005356)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

35 references — full list in the complete paper: https://tomesphere.com/paper/PMC12156808/full.md

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Source: https://tomesphere.com/paper/PMC12156808