# Synthesis of Ethynyl Trifluoromethyl Sulfide and Its Application to the Synthesis of CF3S-Containing Triazoles

## TL;DR

This paper introduces a new chemical building block that efficiently creates triazole compounds with a SCF3 group.

## Contribution

The first use of ethynyl trifluoromethyl sulfide as a building block for synthesizing CF3S-containing triazoles.

## Key findings

- Ethynyl trifluoromethyl sulfide reacts with azides to form 1,4-disubstituted triazoles with SCF3 groups.
- The method produced 15 examples with yields up to 86% under copper-catalyzed conditions.

## Abstract

The unprecedented use of ethynyl trifluoromethyl sulfide (CF3S–C≡CH) as a synthetically useful building block has been described for the first time. It was reacted with various aromatic and aliphatic azides under copper-catalyzed conditions to yield a novel class of 1,4-disubstituted triazoles bearing the SCF3 group (15 examples, up to 86% yield).