# Genetic Variants in Preeclampsia During Pregnancy: A Hospital-Based Case–Control Study

## TL;DR

This study identifies specific genetic variants linked to preeclampsia risk in a Kazakhstani population, but highlights the need for larger studies to confirm their significance.

## Contribution

The study reports novel associations between three SNPs and preeclampsia in a specific geographic cohort.

## Key findings

- rs2516839 (C/T) showed a 5.28-fold increased risk of preeclampsia.
- rs17672135 (T/T) was associated with a 3.48-fold higher risk.
- rs10757278 (A/G) was linked to a 0.3-fold reduced risk.

## Abstract

Background/Objectives: Preeclampsia is a multifactorial disorder with a possible genetic component. While numerous studies have explored genetic susceptibility, validation remains inconsistent. The aim was to assess the association between hypertension-related polymorphisms and preeclampsia risk. Methods: A case–control study was conducted in Karaganda, Kazakhstan (n = 95). Sixty SNPs were genotyped using the QuantStudio™ 12K Flex system. Genotype–phenotype associations were evaluated using five inheritance models and statistical analysis in R. Results: Significant associations were found for rs2516839 (C/T: OR = 5.28; 95% CI: 1.53–18.15), rs17672135 (T/T: OR = 3.48; CI: 1.05–11.5), and rs10757278 (A/G: OR = 0.3; CI: 0.11–0.83). However, wide confidence intervals suggest potential limitations in sample size and generalizability. Conclusions: While these polymorphisms show promise as genetic markers of preeclampsia risk, their clinical application requires further validation in larger, multi-ethnic cohorts.