Antiproliferative Water-Soluble Mono- and Binuclear Ruthenium Complexes with Pyridone–Imidazole Ligands
Ilya A. Shutkov, Nikolai A. Melnichuk, Sofya A. Ovakimyan, Dmitrii M. Mazur, Nataliya E. Borisova, Maxim L. Kuznetsov, Ivan A. Godovikov, Konstantin A. Lyssenko, Dmitrii S. Yakovlev, Alexander A. Spasov, Elena R. Milaeva, Alexey A. Nazarov
TL;DR
Scientists created new water-soluble ruthenium compounds with antiproliferative effects on cancer cells without harming normal cells.
Contribution
The study introduces a new class of water-soluble ruthenium complexes with pyridone–imidazole ligands showing antiproliferative activity.
Findings
The compounds showed antiproliferative activity in human cancer cell lines.
They were non-cytotoxic to primary rat fibroblasts up to 1000 µM.
Binuclear metallocycles resisted hydrolysis and induced apoptosis in tumor cells.
Abstract
In this study, we synthesized and characterized new imidazole ligands containing pyridone groups, as well as mononuclear and binuclear ruthenium complexes, which are a new class of water-soluble metallacycles. We studied the antiproliferative activity of these compounds in vitro using the MTT assay on a panel of human cancer cell lines and on primary rat fibroblasts, where we observed a complete absence of cytotoxicity up to a concentration of 1000 µM. For the binuclear metallocycle compounds, we investigated their solubility in water, resistance to hydrolysis, and ability to induce apoptosis in tumor cells.
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Taxonomy
TopicsMetal complexes synthesis and properties · Ferrocene Chemistry and Applications · Asymmetric Hydrogenation and Catalysis