# Influence of Surgical Procedures on C-Reactive Protein Levels in Severely Burned Patients: Preliminary Analysis on Implications for Early Sepsis Diagnosis

## TL;DR

This study examines how different surgical procedures affect C-reactive protein levels in severely burned patients, which could help in early sepsis diagnosis.

## Contribution

The study provides preliminary data on how surgical procedures influence CRP levels, offering insights into early sepsis detection in burn patients.

## Key findings

- CRP levels decreased three hours post-procedure in patients undergoing skin harvesting for grafting.
- CRP levels significantly increased in patients who had tangential necrectomy.
- Monitoring CRP around surgical procedures may help assess inflammatory responses in burn patients.

## Abstract

The local treatment of deep burn wounds involves the excision of the necrosis and covering the wounds with skin grafts. Surgical procedures are thought to have an impact on the inflammatory response, especially in severe burn patients requiring treatment in an intensive care unit. Currently, there are no available data in the literature regarding the correlation of the type of surgical procedure and the levels of the inflammatory markers. This study investigates the importance of monitoring c-reactive protein (CRP) around the time of surgical burn procedures and how it can aid in assessing the inflammatory response. Of the 810 burn patients, 93 patients aged 20 to 74 years with IIb- and III-degree burns covering 20% to 50% of the total burned body surface were included in this prospective study. Three subgroups were recognized based on the surgical procedure performed: fascial necrectomy, tangential necrectomy, and skin grafting. The research material included blood samples collected in the early postoperative hours. A total of 270 CRP level measurements were performed. A reduction in CRP levels was observed three hours post-procedure in patients who underwent skin harvesting for grafting. Conversely, a significant increase in CRP levels was noted between postoperative timepoints in patients who underwent tangential necrectomy.