Infrequent Histopathologic Subtypes of Oral Squamous Cell Carcinoma: A Case Series with Emphasis on Histopathologic Characteristics

TL;DR

This paper presents four rare types of oral cancer and highlights their unique microscopic features to improve accurate diagnosis.

Contribution

The study provides a detailed histopathologic analysis of four infrequently encountered oral SCC subtypes to aid in their correct diagnosis.

Findings

The paper describes four rare oral SCC variants: spindle cell, cuniculatum, papillary, and basaloid SCC.

Each case emphasizes distinct histopathologic features critical for accurate diagnosis.

Proper identification of these subtypes is essential to avoid misdiagnosis and ensure appropriate treatment.

Abstract

Squamous cell carcinoma (SCC) is the most common oral malignancy. Conventional types are classified as well-, moderately- and poorly differentiated, which are usually easy to diagnose microscopically. Still,
uncommon variants such as basaloid, verrucous, spindle cell, papillary, adenosquamous, acantholytic, cuniculatum, clear cell, and pigmented SCC make a diagnostic challenge for pathologists. This report presents
four rare cases of oral SCC with histopathologic diagnosis of spindle cell carcinoma, carcinoma cuniculatum, papillary SCC, and basaloid SCC focusing on microscopic characteristics and differential diagnosis.
The apprehensive knowledge about the unique histopathologic features of these uncommon variants is crucial to avoid their misdiagnoses and provide appropriate treatment.

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