Synthesis with control of DNA nanoflowers towards biomedical applications
Nsolo M. Maarifa, Fahim El-Kassim M. Issimail, Jian He, Xingyi Ma
TL;DR
DNA nanoflowers are being studied for biomedical uses due to their unique structure and properties, with a focus on how they can be controlled and applied in sensing, imaging, and drug delivery.
Contribution
This review provides insights into the design, synthesis, and control of DNA nanoflowers for biomedical applications.
Findings
DNFs offer high loading capacity due to their large surface area and roughness.
DNFs can be used in biosensing, bioimaging, and drug delivery due to their programmability and biocompatibility.
Challenges remain in controlling DNF structure and interactions with inorganic materials.
Abstract
Along with the advancement of DNA nanotechnology, DNA nanomaterials have been extensively explored and applied in the biomedical field. DNA nanoflowers (DNFs), characterized as flower-shaped nanocrystals, have attracted notable interest in the biomedical field because of their large surface area relative to volume and significant surface roughness; enabling high loading capacity. Due to their unique sequence programmability, function designability, and biocompatibility, DNFs have increasingly been researched in biosensing, bioimaging and, drug delivery and therapy. Self-assembly of DNFs enables them to maintain DNA stability and provides additional functions of metal ions, which are difficult to obtain through conventional methods. However, some challenges must be addressed, such as the interaction between DNA and inorganic material and controlling the structural features like petals…
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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Taxonomy
TopicsAdvanced biosensing and bioanalysis techniques · Gold and Silver Nanoparticles Synthesis and Applications · Biosensors and Analytical Detection