# The role of IL-17-related signaling in myelomagenesis, disease prognosis/progression, and therapeutic approach—a scoping review

## TL;DR

This review explores how IL-17 signaling contributes to multiple myeloma and how targeting it could improve treatment.

## Contribution

The paper highlights IL-17-related signaling as a novel and underexplored therapeutic target in multiple myeloma.

## Key findings

- IL-17 promotes plasma cell growth and is linked to myeloma development and progression.
- Monoclonal antibodies targeting the IL-17 axis are already in clinical use for other conditions.
- Therapeutic interference with IL-17 signaling may offer new treatment strategies for multiple myeloma.

## Abstract

Multiple myeloma (MM), a plasma cell malignancy, despite the progress in treatment, is still a challenge for both clinicians and affected patients. Modern treatment regimens including monoclonal antibodies, bispecific antibodies, CAR-T cell therapy as well as new generations of immunomodulatory drugs and proteasome inhibitors significantly improved clinical outcomes. Nonetheless, there is still a room for improvement and novel therapeutic strategies. IL-17-related signaling is a relatively undiscovered area in MM research. It was established that IL-17 is the growth factor for plasma cells including their malignant counterparts, is associated with myelomagenesis and disease progression. Furthermore, IL-17 axis can be pharmacologically targeted by monoclonal antibodies currently being used in different indications. In this narrative review we summarized the role of IL-17 axis in MM. Specifically, we focused on the role of IL-17 in MM development and progression with a particular emphasis upon clinical implications. Moreover, we have briefly summarized the potential role of therapeutic interference with IL-17-related singling and have outlined future research directions.