Hepatoprotective activity of raspberry ketone against streptozotocin-induced type 2 diabetes in male rats
Dalia Fouad, Doaa M. Elnagar, Ghaida Eid, Esraa Shuker
TL;DR
Raspberry ketone may protect the liver from diabetes-related damage in rats by reducing oxidative stress and inflammation.
Contribution
This study demonstrates raspberry ketone's hepatoprotective effects in a streptozotocin-induced diabetes model in rats.
Findings
Raspberry ketone reduced liver damage and oxidative stress in diabetic rats.
Raspberry ketone showed anti-inflammatory and antiapoptotic effects in the liver.
Raspberry ketone improved blood and lipid profiles in diabetic rats.
Abstract
Type 1 diabetes encompasses a spectrum of metabolic disorders marked by insulin deficiency, resulting in elevated blood glucose levels, commonly referred to as hyperglycemia. This persistent condition often precipitates lipid profile abnormalities, causing cholesterol alterations, low-and high-density lipoproteins, and triglycerides. The liver is particularly vulnerable to increased oxidative stress and inflammatory responses, which activate the transcription of pro-apoptotic genes and ultimately contribute to hepatocyte damage. This study analyzed the potential therapeutic role of raspberry ketone (RK), a natural antioxidant with antiapoptotic and anti-inflammatory properties, in male albino rats with induced type 2 diabetes. Fifty rats were equally divided into five groups: control, rats orally administered 200 mg /kg Body Weight (BW) RK for 5 days, diabetic rats intramuscularly…
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Taxonomy
TopicsDiet, Metabolism, and Disease · Liver Disease Diagnosis and Treatment · Natural Antidiabetic Agents Studies