TMEM138: From Biological Functions to Diseases
Qinghan SHI, Lingling ZHU, Lan ZHANG, Zhaolun GUO, Yafei HAO, Yongmei WANG, Jiangang GAO, Hua LI, Min LIU
TL;DR
This review summarizes TMEM138's biological roles and its connection to diseases like neurodegenerative disorders and tumors.
Contribution
The paper offers a comprehensive overview of TMEM138's molecular features and disease associations.
Findings
TMEM138 is involved in cell proliferation, differentiation, and apoptosis.
Abnormal TMEM138 expression is linked to neurodegenerative diseases and tumors.
The review highlights TMEM138's potential roles in disease pathogenesis.
Abstract
Transmembrane Protein 138 (TMEM138) is a transmembrane protein belonging to the superfamily of transmembrane proteins. Recent research has unveiled its involvement in various biological processes such as cell proliferation, differentiation, and apoptosis. Furthermore, abnormal expression of TMEM138 has been linked to a range of diseases, particularly neurodegenerative diseases and tumors. This review provides an overview of TMEM138, focusing on its molecular characteristics, biological functions, and potential roles in disease pathogenesis. The aim is to offer a valuable reference for future research and clinical applications.
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Taxonomy
TopicsGenetic and Kidney Cyst Diseases · Amino Acid Enzymes and Metabolism · Renal and related cancers