Efficacy of trimetazidine for myocardial ischemia-reperfusion injury in rat models: a systematic review and meta-analysis

TL;DR

This study reviews how well trimetazidine protects rat hearts from injury caused by reduced blood flow and reperfusion.

Contribution

A systematic review and meta-analysis of trimetazidine's effects on rat models of myocardial ischemia-reperfusion injury.

Findings

Trimetazidine increased superoxide dismutase levels and reduced malondialdehyde, lactate dehydrogenase, and CK-MB in rat MIRI models.

The drug's effectiveness was influenced by ischemia duration, reperfusion time, dosage, and administration method.

Trimetazidine showed significant protective effects when administered intravenously or via gavage at 3–10 mg/kg.

Abstract

Trimetazidine (TMZ) is used as a medication for ischemic heart disease treatment. Recently, several animal models have been studied in relation to the research on myocardial ischemia-reperfusion injury (MIRI) treatment. In this study, we conducted a meta-analysis of TMZ in rat MIRI models to evaluate TMZ’s therapeutic efficacy.

We systematically searched eight databases for studies on TMZ in rat MIRI models. We utilized two literature quality assessment criteria to evaluate the paper quality. Assessment of TMZ treatment efficacy was based on the outcomes, as well as on the subgroup analysis. This study was registered at PROSPERO (registration number CRD42022377728).

After applying the inclusion and exclusion criteria, 24 eligible studies were shortlisted from 405 studies. We found that, in rat MIRI models, TMZ dramatically boosted the superoxide dismutase (SOD) levels while decreasing the levels of malondialdehyde (MDA), lactate dehydrogenase (LDH), and creatine kinase isoenzyme (CK-MB), and the infarct size. In addition, the duration of myocardial ischemia, reperfusion duration, dosage, rat species and mode of administration influenced the effectiveness of TMZ. The result indicated that TMZ had a considerable therapeutic effect on the duration of myocardial ischemia at less than 30 min as well as on the duration of reperfusion at 120–180 min. In fact, it was more effective when administered intravenously and via gavage at doses of 3–10 mg/kg.

TMZ can attenuate the damage caused by MIRI in rat, with a myocardial protective effect. These findings would facilitate preclinical evidence for further investigation.

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