# Use of Brazilian flora as the main source of new antimalarials: a systematic review

## TL;DR

This paper reviews how plants from Brazil's rich biodiversity, especially the Amazon, can provide new antimalarial compounds to combat drug-resistant malaria.

## Contribution

The study systematically reviews Brazilian flora's potential as a source of new antimalarial compounds using PRISMA guidelines.

## Key findings

- Most antimalarial compounds were isolated from the Amazon Rainforest in northern Brazil.
- Alkaloids from the Apocynaceae family showed significant antiplasmodial activity.
- Further research is needed to understand the full potential of these natural compounds.

## Abstract

Plants represent an important source of compounds for treating malaria, highlighting the rich biodiversity of Brazilian flora as a vital resource for developing new, effective antimalarial drugs. The present study sought to shed light on the search for new compounds with antimalarial activity obtained from the Brazilian flora. In this sense, a systematic review was conducted using screening techniques based on “The Preferred Reporting Items for Systematic Reviews and Meta-Analysis” (PRISMA) protocol. Most of the plants collected in the studies were from the Amazon Rainforest, north of Brazil. Most of the isolated compounds were from the Apocynaceae family and the alkaloids were the main compounds isolated with significant antiplasmodial activity, followed by flavonoids and phenolic compounds. The Brazilian flora can source many compounds with potential antimalarial activity that can challenge Plasmodium drug resistance. However, new studies are still needed to elucidate the natural compounds activity for future application in Malaria treatment.