# Piperacillin-Tazobactam-Induced Generalized Exanthematous Pustulosis

## TL;DR

A 58-year-old woman developed a rare skin condition after using piperacillin-tazobactam, which improved after stopping the medication.

## Contribution

Reports a rare case of AGEP caused by piperacillin-tazobactam confirmed by histopathology.

## Key findings

- AGEP occurred in a patient using piperacillin-tazobactam.
- Histopathology showed neutrophilic pustules and eosinophilic infiltration.
- Symptoms resolved within three days after discontinuing the drug.

## Abstract

Acute generalized exanthematous pustulosis (AGEP) is an extremely rare condition that is mostly caused by antibiotic exposure. Clinically, it manifests as the rapid appearance of multiple sterile pustules, swelling, and erythema within a few hours to days of exposure to the offending medication. Skin lesions usually resolve by desquamation after discontinuation of the offending agent. We present a case of a 58-year-old female patient with AGEP in the setting of piperacillin-tazobactam use, which was confirmed by histopathology with findings of neutrophilic pustules and eosinophilic infiltration. Her symptoms started resolving within three days of stopping the medication.