# A Randomised Cross‐Over Study to Evaluate the Physiological Effects of Internal Air Pressure Changes in Advanced Support Surface Design

**Authors:** Silvia Caggiari, Martin Toms, Rehorova Lucie, Zara Evans, Ralph Gordon, Paul Muckelt, Florence Mbithi, Davide Filingeri, Peter R. Worsley

PMC · DOI: 10.1111/iwj.70703 · International Wound Journal · 2025-06-08

## TL;DR

This study examines how different mattress air pressure settings affect tissue physiology in various postures, finding posture has a bigger impact than pressure changes.

## Contribution

The study introduces new insights into how posture and mattress inflation speed influence sacral tissue perfusion and pressure.

## Key findings

- No significant differences in peak pressure index values were found across different mattress inflation cycle speeds.
- High sitting posture significantly increased sacral contact area and induced ischemic responses with fast and normal inflation speeds.
- Slow inflation speed improved tissue perfusion in most participants.

## Abstract

High specification mattresses periodically redistribute pressure using alternating air cells, offloading tissues. This study aimed to evaluate the effects of alternating air pressure gradients on sacral tissue physiology. This randomised cross‐over study recruited 15 healthy participants to test the three mattress settings (fast cycle, normal cycle, and slow cycle). Participants were asked to adopt supine, lateral, and high sitting (head of bed at 40°) postures, whilst transcutaneous tissue gas tensions and interface pressures at the sacrum were continuously monitored. Comparison between mattress settings and postures showed no statistical difference (p > 0.05) between peak pressure index values at the sacrum for each air inflation cycle speed setting. By contrast, a significantly higher sacral (p < 0.05) contact area was observed for high sitting. During high sitting, ischemic responses during both fast and normal air inflation cycle speed settings were recorded. During the slow air inflation cycle speed, most participants (60%–100%) showed high levels of perfusion. The present study identified a main effect of posture on interface pressure and perfusion over the sacrum. The alternating mattress speed influenced local tissue perfusion, with the greatest changes in tissue oxygenation occurring in a high‐speed setting.

## Full-text entities

- **Diseases:** ischemic (MESH:D002545)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12145981/full.md

## References

34 references — full list in the complete paper: https://tomesphere.com/paper/PMC12145981/full.md

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Source: https://tomesphere.com/paper/PMC12145981