# MT-45: A Synthetic Opioid With an Unusual Adverse Effect Profile

## TL;DR

MT-45 is a synthetic opioid linked to rare and unusual side effects like hearing loss and hair changes.

## Contribution

The paper introduces MT-45 and highlights its unique adverse effect profile not commonly seen with other opioids.

## Key findings

- Three patients experienced ototoxicity after exposure to MT-45.
- Another three patients showed symptoms like visual impairment, dry eye, and hair changes.
- MT-45 should be considered in diagnosing patients with rare adverse effects.

## Abstract

The opioid crisis continues to be a problem in the United States. The rise of illicit synthetic opioids continues to be a threat to those that may unknowingly digest these substances. Herein, we present a synthetic opioid, MT-45, that has an unusual adverse effect profile. In one case series, three patients experienced ototoxicity. In a separate case series, three patients experienced a range of symptoms that included visual impairment, dry eye disorder, dermatitis, Mee's lines, alopecia, and hair depigmentation. Clinicians should consider MT-45 as part of their differential diagnosis if a patient is experiencing an uncommon adverse effect associated with MT-45.