# Pneumocystis Pneumonia in a Non-AIDS Patient

**Authors:** Adel N Shalabi, Taha Saleem, Neel H Patel, Lauren E Blewett, James L Crowe

PMC · DOI: 10.7759/cureus.83746 · Cureus · 2025-05-08

## TL;DR

This paper reports a rare case of Pneumocystis pneumonia in a non-AIDS HIV patient, highlighting the importance of considering this condition in patients with lung symptoms.

## Contribution

The novelty lies in documenting PCP in a non-AIDS HIV patient, expanding the understanding of PCP susceptibility beyond traditional criteria.

## Key findings

- PCP can occur in non-AIDS HIV patients with certain CD4 T-cell counts.
- PCP should be considered in the differential diagnosis for HIV patients with acute lung disease.
- Comorbidities may influence PCP risk in HIV patients outside of AIDS.

## Abstract

We present a unique case of Pneumocystis jirovecii pneumonia (PCP) in a patient with HIV. Both treated and untreated HIV patients are susceptible to opportunistic pathogens. Depending on the patient’s underlying cluster of differentiation 4 T-cell (CD4 T-cell) count, HIV is associated with a wide range of infections. Historically, PCP has been observed in HIV patients with AIDS or in those receiving immunosuppressive therapy. However, it should remain a differential diagnosis in patients who present with comorbidities and symptoms of acute lung disease.

## Linked entities

- **Diseases:** Pneumocystis pneumonia (MONDO:0019121), AIDS (MONDO:0012268)
- **Species:** Pneumocystis jirovecii (taxon 42068)

## Full-text entities

- **Genes:** CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}
- **Diseases:** acute lung disease (MESH:D055371), pneumonia (MESH:D011014), AIDS (MESH:D000163), PCP (MESH:D011020), opportunistic (MESH:D009894), infections (MESH:D007239)
- **Species:** Homo sapiens (human, species) [taxon 9606], Human immunodeficiency virus 1 (no rank) [taxon 11676]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC12145197/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC12145197/full.md

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Source: https://tomesphere.com/paper/PMC12145197