# Universal and economical experimental platform for colloidal mixing lab-on-chip in parabolic flight

**Authors:** Saran Seehanam, Hein Htet Aung, Rattanawalee Tobsri, Yossaphol Kaewkumpha, Chanud Sithipreedanant, Nachanok Kladsamniang, Witsaroot Sripumkhai, Pattaraluck Pattamang, Potiwat Ngamkajornwiwat, Wanassanan Chansataporn, Wares Chancharoen

PMC · DOI: 10.1038/s41598-025-04368-8 · Scientific Reports · 2025-06-06

## TL;DR

This paper introduces a low-cost platform for studying fluid mixing in microgravity during parabolic flights, showing how surfactants like Span 80 improve mixing efficiency.

## Contribution

The novel contribution is an economical and modular platform for real-time colloidal mixing experiments under microgravity conditions.

## Key findings

- The platform successfully captured fluid dynamics at 240 frames per second during 29 parabolic flight trials.
- Span 80 emulsions showed a 24.2% improvement in mixing compared to the microgravity control.
- The system allows for future studies on surfactant and mixer geometry effects at real-world scales.

## Abstract

This study presents an economical experimental platform designed to investigate colloid and emulsion mixing under parabolic flight conditions. The compact 20 kg system integrates a modular fluidic device with real-time imaging capabilities to enable the observation of fluid interactions at the millimeter scale. The platform focuses on safety, like a double containment system, while remaining accessible for quick experimental modifications. Experiments using four distinct colloids, Thailand Lunar Simulant (TLS-01A), emulsions with Span 80 (50% v/v) and Tween 80 (10% v/v), and a control without additives, enabled analysis of surface tension and particle effects on mixing behavior. Through 29 experimental trials during parabolic flight cycles, each with approximately 20 s of microgravity, the system captured fluid dynamics at 240 frames per second. The platform enables future research to observe effects of surfactant and mixer geometry in real-world scale, with potential for improvements in automation and imaging capabilities. Using a simple measure of color distribution entropy, the Span 80 sample exhibited the highest degree of mixing, with a 24.2% improvement over the microgravity control and a 19.4% increase relative to ground-based Span sample.

## Linked entities

- **Chemicals:** Span 80 (PubChem CID 347521), Tween 80 (PubChem CID 443315)

## Full-text entities

- **Chemicals:** Tween 80 (MESH:D011136), Span 80 (MESH:C018665)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12144302/full.md

## Figures

10 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12144302/full.md

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Source: https://tomesphere.com/paper/PMC12144302