# Influence of endurance versus resistance exercise training on central and peripheral chemoreflexes in young healthy individuals

## TL;DR

This study found that endurance and resistance exercise training do not change chemoreflex sensitivity in young healthy individuals.

## Contribution

The study is the first to compare the effects of endurance and resistance training on chemoreflex sensitivity in young humans.

## Key findings

- Endurance and resistance training did not alter central chemoreflex sensitivity in young individuals.
- Peripheral chemoreflex sensitivity remained unchanged across all training groups.
- No significant differences were observed in ventilatory responses between the groups.

## Abstract

Heightened central and peripheral chemoreflex sensitivity are associated with poor outcomes, but therapeutic approaches to target them are lacking. Endurance and resistance exercise training improve a multitude of physiological outcomes, but their effects on ventilatory chemoreflex sensitivity are unclear. Accordingly, the cardiorespiratory responses to steady-state isocapnic hypoxia (10 % O2, 5-minutes) and hyperoxic hypercapnic rebreathing (5 % CO2-95 % O2) were compared in endurance, resistance, and untrained groups. Central chemoreflex sensitivity was taken as the slope of the relationship between minute ventilation (V̇E) and end-tidal partial pressure of CO2. Peripheral chemoreflex sensitivity was determined from the absolute increase in V̇E from baseline to peak V̇E expressed relative to the fall in oxygen saturation. Neither central (P = 0.093) nor peripheral (P = 0.847) ventilatory chemoreflex sensitivities were different between groups. Future investigations should seek to understand whether exercise training modality influences central and peripheral chemoreflex sensitivity in older and clinical populations.

•Heightened chemoreflex sensitivity is associated with poor outcomes.•Exercise training improves central and peripheral chemoreflex sensitivity in animals.•Central chemoreflex (hypercapnia) responses were not different in young humans.•Peripheral chemoreflex (hypoxia) responses were also not different in young humans.

Heightened chemoreflex sensitivity is associated with poor outcomes.

Exercise training improves central and peripheral chemoreflex sensitivity in animals.

Central chemoreflex (hypercapnia) responses were not different in young humans.

Peripheral chemoreflex (hypoxia) responses were also not different in young humans.