# Empowering integrative and collaborative exploration of single-cell and spatial multimodal data with SGS genome browser

**Authors:** Tingting Xia, Jiahe Sun, Yongjiang Luo, Hailong Guo, Yudi Mao, Ling Xu, Fang Lu, Yi Wang

PMC · DOI: 10.1016/j.xgen.2025.100848 · Cell Genomics · 2025-04-14

## TL;DR

SGS is a browser that helps researchers explore and visualize complex single-cell and spatial genomic data in a collaborative way.

## Contribution

SGS introduces a versatile browser with advanced visualization modes and collaborative features for multimodal single-cell and spatial data.

## Key findings

- SGS supports integrative visualization of single-cell and spatial multimodal data.
- SGS enables 3D spatially resolved transcriptomics data visualization with surface model plots.
- SGS allows comparative visualization through features like scCompare and dual-chromosome mode.

## Abstract

Recent advancements in single-cell and spatial omics technologies have generated a large amount of complex, high-dimensional data, which poses significant challenges to visualization tools. We introduce SGS (single-cell and spatial genomics system), a user-friendly, collaborative, and versatile browser designed for visualizing single-cell and spatial multimodal data. SGS excels in the integrative visualization of complex multimodal data, offering an innovative genome browser, flexible visualization modes, and 3D spatially resolved transcriptomics (SRT) data visualization capabilities. Notably, SGS empowers users with advanced capabilities for comparative visualization through features like scCompare, scMultiView, and the dual-chromosome mode. It supports a variety of data formats and is compatible with established analysis tools, enabling collaborative data exploration and visualization without programming. Overall, SGS is a comprehensive browser that enables researchers to unlock novel insights from multimodal data.

•SGS is a user-friendly tool for scMulti-omics data visualization and collaboration•Enhances the visualization of genome-mapped data and multi-panel coordination•SGS enables cross-modal, spatial tissues and features visualization comparisons•SGS archives the 3D transcriptomic data visualization with surface model plots

SGS is a user-friendly tool for scMulti-omics data visualization and collaboration

Enhances the visualization of genome-mapped data and multi-panel coordination

SGS enables cross-modal, spatial tissues and features visualization comparisons

SGS archives the 3D transcriptomic data visualization with surface model plots

SGS is a user-friendly, collaborative, and versatile browser for visualizing single-cell and spatial multiomics data. With advanced features for comparative visualization, multi-panel coordinate view, abundant visualization functions, and collaborative exploration, SGS empowers researchers to unlock novel insights from scMulti-omics data.

## Full-text entities

- **Genes:** Ttr (transthyretin) [NCBI Gene 22139] {aka prealbumin}, Mal-A3 (Maltase A3) [NCBI Gene 35826] {aka CG8695, Dmel\CG8695, Drome_A3, L, LvpL, V}, BLK (BLK proto-oncogene, Src family tyrosine kinase) [NCBI Gene 640] {aka MODY11}, kay (kayak) [NCBI Gene 3772082] {aka AP-1, AP1, Ap1, CG15507, CG15509, CG33956}, PENK (proenkephalin) [NCBI Gene 5179] {aka PE, PENK-A}, grh (grainy head) [NCBI Gene 37038] {aka BcDNA:LD38807, CG30111, CG42311, CG5058, DREB, Dmel\CG42311}, Hpca (hippocalcin) [NCBI Gene 15444], Xcl1 (chemokine (C motif) ligand 1) [NCBI Gene 16963] {aka ATAC, LTN, Lptn, SCM-1, SCM-1a, Scyc1}, Try29F (Trypsin 29F) [NCBI Gene 34226] {aka CG9564, Dmel\CG9564, SP106, try29F.2, trypsin29F}, Rbp6 (RNA-binding protein 6) [NCBI Gene 39919] {aka BcDNA:RE25373, CG14055, CG14056, CG32169, CG6573, Dmel\CG32169}, CD4 (CD4 molecule) [NCBI Gene 920] {aka CD4mut, IMD79, Leu-3, OKT4D, T4}, Prkcd (protein kinase C, delta) [NCBI Gene 18753] {aka D14Ertd420e, PKC[d], PKCdelta, Pkcd}, Stx1a (syntaxin 1A (brain)) [NCBI Gene 20907] {aka HPC-1}, Rarg (retinoic acid receptor, gamma) [NCBI Gene 19411] {aka Nr1b3, RAR-gamma, RARD, RARgamma2}, Mef2 (Myocyte enhancer factor 2) [NCBI Gene 36032] {aka 22.21, BEST:SD04091, C, CG1429, D-MEF2, D-Mef2}, NRXN2 (neurexin 2) [NCBI Gene 9379], srp (serpent) [NCBI Gene 41944] {aka A7.1, ABF, Abf, CG3992, DmGATAb, Dmel\CG3992}, FOXP2 (forkhead box P2) [NCBI Gene 93986] {aka CAGH44, SPCH1, TNRC10}, MFSD11 (major facilitator superfamily domain containing 11) [NCBI Gene 79157] {aka ET}, RORB (RAR related orphan receptor B) [NCBI Gene 6096] {aka EIG15, NR1F2, ROR-BETA, RORbeta, RZR-BETA, RZRB}, CD8A (CD8 subunit alpha) [NCBI Gene 925] {aka CD8, CD8alpha, IMD116, Leu2, p32}
- **Diseases:** SGS (MESH:D008569)
- **Species:** Mus musculus (house mouse, species) [taxon 10090], Drosophila melanogaster (fruit fly, species) [taxon 7227], Homo sapiens (human, species) [taxon 9606]
- **Mutations:** rs2736336
- **Cell lines:** ME11 — Homo sapiens (Human), Melanoma, Cancer cell line (CVCL_L912)

## Full text

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## Figures

8 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12143324/full.md

## References

51 references — full list in the complete paper: https://tomesphere.com/paper/PMC12143324/full.md

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Source: https://tomesphere.com/paper/PMC12143324