# Icaritin and lenvatinib treatment for unresectable localized progressive pancreatic cancer: a report of six cases

## TL;DR

This paper reports on six cases of advanced pancreatic cancer treated with a combination therapy including icaritin, showing varying degrees of improvement.

## Contribution

The study introduces a novel treatment regimen combining icaritin with other therapies for advanced pancreatic cancer.

## Key findings

- Partial responses with tumor shrinkage were observed in two cases.
- Two cases showed limited relief with slight tumor size reduction.
- No significant lesion progression was noted in two other cases.

## Abstract

Pancreatic cancer is very difficult to detect in its early stages, and its rapid progression and poor prognosis make it a significant therapeutic challenge. Existing treatment modalities, whether standalone or combined, offer limited efficacy, highlighting an urgent need for more effective and less toxic therapeutic strategies.

We analyze six cases of pancreatic cancer, each undergoing a novel treatment regimen integrating chemotherapy, targeted therapy, immune therapy, and icaritin.

The outcomes demonstrate varying degrees of improvement in all cases. Partial responses were observed in cases 1 and 3, with some tumor shrinkage. Cases 4 and 5 showed limited relief following a slight decrease in tumor size. In cases 2 and 6, no significant progression of the lesion was observed. These results highlight the potential efficacy of this multifaceted approach.

Integrating icaritin with chemotherapy, immunotherapy, and/or targeted therapies shows potential as an exploratory approach in managing advanced, locally progressive, or metastatic pancreatic cancer, though further validation is required.