# Redo bilateral lung transplantation in a previous heart-lung transplant recipient for invasive pulmonary scedosporiosis

**Authors:** Akshay Chauhan, Nischal Ranganath, John P. Scott, Paschalis Vergidis, Anja C. Roden, Philip J. Spencer, Mauricio A. Villavicencio, Richard C. Daly, Sahar A. Saddoughi

PMC · DOI: 10.1016/j.jhlto.2025.100247 · JHLT Open · 2025-04-01

## TL;DR

A rare case of redo-bilateral lung transplant in a heart-lung transplant recipient was successfully managed with surgery and antifungal treatment.

## Contribution

This case report presents a successful surgical and medical management approach for a rare complication in heart-lung transplant recipients.

## Key findings

- The patient showed no issues with bronchial anastomosis healing after the redo-bilateral lung transplant.
- A combination of inhaled antifungal drugs led to a positive 1-year outcome for the patient.
- The case demonstrates a viable strategy for managing invasive pulmonary scedosporiosis in transplant recipients.

## Abstract

Redo-bilateral lung transplant in previous heart-lung transplant is a rare operation. We describe our surgical and medical management experience with a heart-lung transplant recipient who developed chronic lung allograft dysfunction and invasive Scedosporium apiospermum infection. The patient underwent a redo-bilateral lung transplant followed by a combination of inhaled voriconazole, caspofungin, and olorofim for a prolonged period. We observed no issues with bronchial anastomosis healing, and the patient is doing well on 1-year follow-up. This report outlines a successful management approach to this rare complication of heart-lung transplant recipients.

## Linked entities

- **Chemicals:** voriconazole (PubChem CID 71616), caspofungin (PubChem CID 16119814), olorofim (PubChem CID 91885568)

## Full-text entities

- **Diseases:** lung allograft dysfunction (MESH:D000092122), apiospermum infection (MESH:D007239), pulmonary scedosporiosis (MESH:C000656924)
- **Chemicals:** voriconazole (MESH:D065819), olorofim (MESH:C000626907), caspofungin (MESH:D000077336)
- **Species:** Scedosporium (genus) [taxon 41687], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12142616/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12142616/full.md

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Source: https://tomesphere.com/paper/PMC12142616