# Editorial: Differential activation of cell death pathways in macrophages as a result of adaptation to divergent microenvironment

**Authors:** Krzysztof Guzik, Philippe Saas, David Masson

PMC · DOI: 10.3389/fimmu.2025.1623587 · Frontiers in Immunology · 2025-05-22

## Full-text entities

- **Genes:** NFE2L2 (NFE2 like bZIP transcription factor 2) [NCBI Gene 4780] {aka IMDDHH, NRF2, Nrf-2}, CASP8 (caspase 8) [NCBI Gene 841] {aka ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5}, HVCN1 (hydrogen voltage gated channel 1) [NCBI Gene 84329] {aka HV1, VSOP}
- **Diseases:** cardiovascular, metabolic, and inflammatory diseases (MESH:D002318), atherogenesis (MESH:D050197), diabetic cardiomyopathy (MESH:D058065), necrotic (MESH:D009336), cardiac dysfunction (MESH:D006331), DM (MESH:D009223), calcification (MESH:D002114), cancer (MESH:D009369), heart injury (MESH:D006335), inflammation (MESH:D007249)
- **Chemicals:** Fe2+ (-), hydroxyl radicals (MESH:D017665), ceramide (MESH:D002518), calcium phosphate (MESH:C020243), iron (MESH:D007501)

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC12142045/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC12142045/full.md

---
Source: https://tomesphere.com/paper/PMC12142045