# Generalized anxiety disorder patients' cognitive control in affective contexts

**Authors:** Yuqi Shen, Shasha Zhu, Shiqi Liao, Yuqing Zhao, Zihan Lin, Ke Jiang, Wenjing Yan, Xinhua Shen

PMC · DOI: 10.3389/fpsyt.2025.1506239 · Frontiers in Psychiatry · 2025-05-16

## TL;DR

This study shows that people with generalized anxiety disorder have trouble controlling their thoughts in emotional situations, especially with inhibiting distractions and shifting focus.

## Contribution

The study introduces a detailed analysis of affective control in GAD patients by separating it into inhibition and shifting components.

## Key findings

- GAD patients showed reduced proactive control and increased reactive control during affective inhibition.
- GAD patients had higher shifting costs in both non-affective and affective tasks.
- Deficits in affective control were linked to poorer emotion recognition in GAD patients.

## Abstract

Growing evidence suggests a relationship between deficits in cognitive control and anxiety. However, studies examining cognitive control within affective contexts (affective control) are limited, and the specific characteristics of affective control in patients with Generalized Anxiety Disorder (GAD) remain unclear. This study investigated whether differences exist in cognitive control under affective contexts.

We conduct our research in a population of GAD patients (n = 50) and a healthy control group (n = 50). The affective flanker task measured affective inhibition, while the affective flexibility task assessed affective shifting capabilities.

GAD patients exhibited abnormal affective inhibition, characterized by reduced proactive control related to target stimulus processing and enhanced reactive control associated with distractor resolution. Additionally, GAD patients demonstrated deficits in affective shifting, as indicated by significantly higher shifting costs in both non-affective and affective tasks compared to the healthy control group.

The findings reveal that GAD patients display poorer emotion recognition abilities, indicating deficits in affective control compared to healthy individuals. Our study underscores the importance of measuring affective control by delineating it into distinct components.

## Linked entities

- **Diseases:** Generalized Anxiety Disorder (MONDO:0001942)

## Full-text entities

- **Diseases:** deficits in cognitive control (MESH:D003072), GAD (MESH:C000726808), anxiety (MESH:D001007)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

15 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12141855/full.md

## References

42 references — full list in the complete paper: https://tomesphere.com/paper/PMC12141855/full.md

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Source: https://tomesphere.com/paper/PMC12141855