# Association of Vitamin D Deficiency With Abnormal Electrocardiographic Activity Among Healthy People

## TL;DR

This study found that vitamin D deficiency is linked to changes in heart rate variability and repolarization but not to overall abnormal heart activity in healthy people.

## Contribution

The study provides new evidence on how vitamin D deficiency affects specific electrocardiographic parameters in healthy individuals.

## Key findings

- Vitamin D deficiency significantly reduced PNN50, SDANN, and RMSSD compared to sufficient levels.
- TP-e intervals were significantly prolonged in vitamin D-deficient individuals.
- No significant differences were found in QRS, QTc, JTc, or other heart rate indicators between groups.

## Abstract

In a healthy population, abnormal electrocardiographic activity is linked to an increased risk of cardiovascular events. The connection between vitamin D (VitD) deficiency and aberrant electrocardiographic activity was investigated. We included all papers that looked at the association between VitD deficiency and electrocardiographic activity. Basic information about the research population was gathered, and the quality of the studies that were included was evaluated. Using forest plots, we determined the impact of VitD deficiency on cardiac repolarization and autonomic function. A total of 6 studies with a total of 532 participants were included in the study. VitD deficiency was found in 197 people, whereas VitD insufficiency was found in 63 people, and VitD sufficiency was found in 272. When compared to those who had sufficient VitD, VitD deficiency considerably reduced PNN50, SDANN, and RMSSD (p < 0.05), slightly lowered SDNN (p = 0.05), and lengthened TP‐e (p < 0.05). Heart rate, QRS, QTc, JTc, HF, LF, and RMSDD, on the other hand, did not differ substantially between the two groups (p > 0.05). Insufficient VitD does not appear to be linked to aberrant electrocardiographic activity. VitD deficiency affects heart rate variability (HRV) and ventricular repolarization indexes compared to those with sufficient VitD. VitD insufficiency does not affect the ventricular repolarization index.

This study examined the relationship between vitamin D (VitD) deficiency and abnormal electrocardiograms. Compared with the VitD‐sufficient group, the VitD‐deficient group exhibited significantly lower values for PNN50, SDANN, and RMSSD, as well as slightly reduced SDNN and significantly prolonged TP‐e intervals. No significant differences were observed in other indicators between the two groups. These findings suggest that vitamin D deficiency may not be directly associated with abnormal electrocardiographic activity.