# Primary anorectal melanoma: report of two cases

## TL;DR

This paper reports two rare cases of anorectal melanoma, a deadly cancer with poor survival rates, and describes their treatment and outcomes.

## Contribution

The novelty lies in presenting two distinct clinical cases of anorectal melanoma with different presentations and treatment approaches.

## Key findings

- One patient had a localized lesion treated with surgery and survived for a year.
- The second patient had metastatic disease and was treated with immunotherapy, also surviving for a year.

## Abstract

Anorectal melanoma is a rare and aggressive neoplasm with a poor prognosis; the overall survival rate at 5 years is around 20%. We report two clinical cases involving patients who experienced pain and bleeding associated with an anorectal mass. Histopathological studies confirmed the diagnosis of melanoma. The first case presented with localized disease characterized by a black, pedunculated lesion with irreducible prolapse managed with wide local excision. In the second case, the patient had a fixed, pink anal lesion accompanied by multiple inguinal and retroperitoneal lymphadenopathies. Due to the metastatic nature of the disease, immunotherapy was administered. Both patients remain alive after 1 year of follow-up.