# A Common Medication With a Rare Side Effect: A Case Report of Statin-Induced Necrotizing Autoimmune Myopathy

**Authors:** Meghan Grossmann, Madison Drallmeier, Michelle Jin, Eric Scher

PMC · DOI: 10.7759/cureus.83589 · Cureus · 2025-05-06

## TL;DR

A woman developed a rare muscle disease after taking a common cholesterol-lowering drug.

## Contribution

This case report highlights statin-induced necrotizing autoimmune myopathy as a rare but serious side effect.

## Key findings

- A middle-aged woman on atorvastatin developed severe muscle symptoms and elevated creatine kinase.
- She was diagnosed with statin-induced necrotizing autoimmune myopathy.
- Autoantibodies were implicated in the development of the myopathy.

## Abstract

Statins are commonly used for their cholesterol-lowering properties and are prescribed for primary and secondary prevention of cardiovascular disease. Although they are generally well tolerated, some individuals may experience a rare and serious side effect in which autoantibodies develop and lead to a necrotizing myopathy. Here we present a case of a middle-aged woman chronically on atorvastatin for her hyperlipidemia who acutely developed myalgias, muscle weakness, and persistently elevated creatine kinase, who was eventually diagnosed with statin-induced necrotizing autoimmune myopathy.

## Linked entities

- **Chemicals:** atorvastatin (PubChem CID 60823)
- **Diseases:** hyperlipidemia (MONDO:0021187), necrotizing autoimmune myopathy (MONDO:0016098)

## Full-text entities

- **Diseases:** hyperlipidemia (MESH:D006949), cardiovascular disease (MESH:D002318), muscle weakness (MESH:D018908), Autoimmune Myopathy (MESH:D009135), myalgias (MESH:D063806)
- **Chemicals:** atorvastatin (MESH:D000069059), cholesterol (MESH:D002784)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12140385/full.md

## References

6 references — full list in the complete paper: https://tomesphere.com/paper/PMC12140385/full.md

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Source: https://tomesphere.com/paper/PMC12140385