# The association between the monocyte Chemoattractant protein-1–2518A/G polymorphism and the risk of tuberculosis in the Chinese population: A meta-analysis and systematic review

## TL;DR

This study found that a specific genetic variation in the MCP-1 gene increases the risk of tuberculosis in the Chinese population, especially in non-Han Chinese individuals.

## Contribution

The first meta-analysis to investigate the association between the MCP-1–2518A/G polymorphism and tuberculosis risk in the Chinese population.

## Key findings

- The MCP-1–2518A/G polymorphism significantly increases tuberculosis susceptibility in Chinese individuals.
- Non-Han Chinese individuals with the GG genotype have a higher risk of tuberculosis compared to Han Chinese individuals.
- Meta-analysis results showed increased odds ratios for TB in dominant, recessive, and homozygote models.

## Abstract

•This meta-analysis investigated MCP-1–2518A/G polymorphism in Chinese population.•The MCP-1–2518A/G polymorphism increased tuberculosis susceptibility.•Non-Han Chinese individuals showed a higher risk of tuberculosis.

This meta-analysis investigated MCP-1–2518A/G polymorphism in Chinese population.

The MCP-1–2518A/G polymorphism increased tuberculosis susceptibility.

Non-Han Chinese individuals showed a higher risk of tuberculosis.

No meta-analysis has been conducted on the relationship between the MCP-1–2518A/G gene polymorphism and tuberculosis susceptibility in the Chinese population. The aim of this study was to investigate whether MCP-1–2518A/G polymorphism is associated with susceptibility to TB in Chinese.

Publications addressing the association between the MCP-1–2518A/G polymorphism and TB risk were selected from the PubMed, Embase, CNKI and Wanfang databases. Data were extracted from the studies by two independent reviewers. Statistical analysis was performed using RevMan 5.1 and STATA 12 software.

Ten case-control studies were extracted from 10 articles on polymorphisms involving 1634 TB patients and 1768 controls. The results of the meta-analysis showed that a significantly increased risk for TB was found for Chinese individuals with the polymorphism as follows: dominant model (GG+GA vs. AA Odds Ratio [OR = 1.53], 95 % CI 1.14‒2.07, p = 0.000); recessive model (GG vs. GA+AA Odds Ratio [OR = 1.63], 95 % CI 1.13‒2.35, p = 0.009); and a homozygote comparison (GG vs. AA Odds Ratio [OR = 1.93], 95 % CI 1.19‒3.13, p = 0.008). In the subgroup analysis by ethnicity, significantly elevated risks were found in non-Han Chinese individuals but not in Han Chinese individuals (mutant homozygous GG vs. AA: OR = 3.81, 95 % CI 2.07‒7.00, p = 0.000).

This meta-analysis suggested that the -2518A/G polymorphism of the MCP-1 gene is a risk factor for TB in Chinese individuals. In the GG vs. AA model, non-Han Chinese individuals had a higher risk of tuberculosis than Han Chinese individuals.