# A Case of Type 2 Autoimmune Pancreatitis Suggesting Two Potential Disease Activity Markers

## TL;DR

A rare case of type 2 autoimmune pancreatitis is reported, highlighting potential new biomarkers for disease activity.

## Contribution

The study identifies interleukin-8 and leucine-rich alpha-2 glycoprotein as potential new biomarkers for AIP-2.

## Key findings

- Serum interleukin-8 and leucine-rich alpha-2 glycoprotein may better reflect disease activity in AIP-2 than C-reactive protein.
- AIP-2 was diagnosed in a young woman using endoscopic ultrasound–guided tissue acquisition.
- AIP-2 is less frequently reported and lacks serologic abnormalities and other organ involvement.

## Abstract

Autoimmune pancreatitis (AIP) is divided into 2 main subtypes: type 1 AIP (AIP-1) and type 2 AIP (AIP-2). This report describes a young woman diagnosed with AIP-2 using endoscopic ultrasound–guided tissue acquisition. AIP-2 has been reported less frequently than AIP-1 as serologic abnormalities and other organ involvement except for inflammatory bowel disease are absent. Additional laboratory analyses suggest that serum interleukin-8 and leucine-rich alpha-2 glycoprotein are more efficient disease activity biomarkers than conventional C-reactive proteins. We hope that this case report will contribute to the discovery of diagnostic biomarkers for AIP-2.