# β‑Selective Addition of Pyrroles to Electron-Deficient Alkenes in Both Catalytic and Stoichiometric Modes on B(C6F5)3

## TL;DR

This paper reports a new method for adding pyrroles to electron-deficient alkenes at the beta position using B(C6F5)3.

## Contribution

The study introduces a novel electrophilic aromatic substitution system for beta-selective addition of pyrroles.

## Key findings

- A beta-adduct was successfully formed using B(C6F5)3 in both catalytic and stoichiometric modes.
- The reaction system enables selective addition at the beta-position of pyrroles.
- This contrasts with previous reports that only alpha-adducts were formed.

## Abstract

To the best of our knowledge, the addition of pyrroles
to electron-deficient
alkenes (APEda) via electrophilic aromatic substitution (SEAr) has been reported to occur exclusively at the α-position
of the pyrrole without any formation, even in trace amounts, of a
β-adduct, β-3. In sharp contrast to the prolonged
immutable observation, we established an original SEAr-based
APEda (SEAr-APEda) system applicable to both the catalytic
and stoichiometric synthesis of β-3.