# Rhino-orbital-cerebral mucormycosis in diabetic ketoacidosis: A classic clinical presentation still unknown in Senegal

**Authors:** Khadim Diongue, Sokhna Moumi Daffé, Abdourakhmane Sané, Maguette Ndoye, Mamadou Wagué Gueye, Mor Ngom, Papa Silman Diawara, Stéphane Ranque, Bécaye Fall

PMC · DOI: 10.1016/j.idcr.2025.e02244 · IDCases · 2025-05-04

## TL;DR

A 27-year-old diabetic woman in Senegal died from a rare fungal infection called ROCM, highlighting the need for rapid diagnosis and treatment.

## Contribution

This case report presents a rare and fatal case of ROCM in a young diabetic patient in Senegal.

## Key findings

- ROCM caused by Rhizopus oryzae was diagnosed too late in a 27-year-old woman with diabetic ketoacidosis.
- The patient's symptoms included an erythematous plaque, exophthalmos, and necrosis in the orbitofrontal region.
- The patient died within 3 days due to delayed diagnosis and management of ROCM.

## Abstract

Rhino-orbital-cerebral mucormycosis (ROCM) is an invasive mycosis caused by fungi of the order Mucorales. It mainly affects patients with uncontrolled diabetes. This case report concerns a 27-year-old woman with diabetic ketoacidosis who presented with a large erythematous plaque localised in the right orbitofrontal region with exophthalmos and patches of necrosis that rapidly led to death within 3 days before the diagnosis of ROCM due to Rhizopus oryzae, the causal agent. So, without rapid diagnosis and swift management, ROCM results in a potential fatality.

## Linked entities

- **Diseases:** diabetic ketoacidosis (MONDO:0012819)

## Full-text entities

- **Diseases:** invasive (MESH:D009361), mycosis (MESH:D015821), death (MESH:D003643), ROCM (MESH:D009091), necrosis (MESH:D009336), uncontrolled diabetes (MESH:D003920), diabetic ketoacidosis (MESH:D016883), exophthalmos (MESH:D005094)
- **Species:** Rhizopus arrhizus (species) [taxon 64495], Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12138463/full.md

## References

20 references — full list in the complete paper: https://tomesphere.com/paper/PMC12138463/full.md

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Source: https://tomesphere.com/paper/PMC12138463