# Management of neurotrophic corneal ulcer with a topical liposomal ozonated oil: A report on three clinical cases

## TL;DR

This paper reports three successful cases of neurotrophic corneal ulcers treated with a new type of eye drop that promotes healing and prevents infection.

## Contribution

The study demonstrates the effectiveness of topical liposomal ozonated oil in treating neurotrophic corneal ulcers.

## Key findings

- Topical liposomal ozonated oil (Ozonest®) led to complete re-epithelialization in three neurotrophic corneal ulcer cases.
- The treatment showed antiseptic properties and prevented superinfection.
- The formulation was well-tolerated and biocompatible with the ocular surface.

## Abstract

To present three cases of neurotrophic corneal ulcer successfully treated with topical liposomal ozonated oil (Ozonest®) eye drops and to assess its potential usefulness in preventing corneal infection and promoting epithelialization.

Neurotrophic corneal ulcers require appropriate therapy that includes re-epithelialization and prevention of infection usually with antibiotic therapy. The emergence of multidrug-resistant bacterial strains due to the overuse of antibiotics in the treatment of infectious diseases has prompted researchers to investigate new antimicrobial formulations. Liposomal ozonated oil has demonstrated antiseptic (antibacterial, antifungal and antiviral) and tissue repair properties, making it a promising candidate for the prevention and treatment of acute and chronic local infections. Additionally, its specific formulation ensures good tolerability and biocompatibility with the ocular surface. In the three cases of neurotrophic ulcer presented here, topical liposomal ozonated oil (Ozonest®) was used, resulting in good resolution and complete re-epithelialization without superinfection.

The use of topical liposomal ozonated oil (Ozonest®) may have an antiseptic role and help in the closure of neurotrophic ulcers.