# Botanical Extract–Infused Shampoo and Hair Tonic for Hair Loss in Androgenetic Alopecia: A TREND‐Compliant, Prospective Single‐Arm Preexperimental Study

## TL;DR

A study found that a botanical extract-infused shampoo and hair tonic improved hair loss and scalp health in men with androgenetic alopecia over six months.

## Contribution

This study introduces a botanical extract-based treatment for AGA with demonstrated efficacy and safety in a clinical setting.

## Key findings

- Hair loss area decreased by an average of 27.35 units (p < 0.0001) after six months of treatment.
- 80% of participants reported significant subjective improvement in hair condition.
- No serious adverse events were observed during the study period.

## Abstract

Androgenetic alopecia (AGA) is the most prevalent form of hair loss, often leading to treatment discontinuation due to the adverse effects and perceived ineffectiveness of conventional treatments. Botanical extracts are gaining attention for their potential benefits in managing AGA with minimal side effects.

To evaluate the efficacy and safety of a shampoo and hair tonic containing Asacurin100, a botanical extract blend, in improving hair loss conditions in patients with AGA.

A prospective single‐group, pretest–posttest study was conducted with 35 male participants diagnosed with AGA at a Korean medicine clinic. Participants applied the shampoo once daily and the hair tonic two to three times daily for 6 months. Data were collected via standardized global scalp photographs and a custom‐designed questionnaire assessing scalp symptoms. Statistical analyses were performed to evaluate changes in hair loss area and subjective symptoms.

The study observed reductions in hair loss area, with a mean decrease of −27.35 ± 26.31 (p < 0.0001), and improvement in all scalp symptom scores. The Patient Global Impression of Change (PGIC) revealed that 80% of participants reported “much” or “very much” improvement in hair condition. No serious adverse events were reported.

The findings suggest that botanical extract–infused shampoo and hair tonic are effective and well‐tolerated treatments for AGA, reducing hair loss and enhancing scalp health. The results warrant further investigation through larger randomized controlled trials to validate the efficacy of plant‐derived compounds for AGA.