# Knowledge of HPV and its association with oropharyngeal cancer among dental students: a systematic review and meta-analysis

## TL;DR

This study finds that most dental students know about HPV and its link to oropharyngeal cancer, but there are significant knowledge gaps that could affect prevention efforts.

## Contribution

The study provides a systematic review and meta-analysis of dental students' knowledge of HPV and its association with oropharyngeal cancer.

## Key findings

- 69% of dental students had general knowledge of HPV, with significant variation across studies.
- 77% recognized the association between HPV and oropharyngeal cancer, but with high heterogeneity.
- Standardized education is recommended to address knowledge gaps among dental students.

## Abstract

Human papillomavirus (HPV) infection is a significant risk factor for oropharyngeal cancer (OPC), yet dental students' knowledge of this association varies widely. Given the critical role dentists play in early detection and prevention, understanding their level of knowledge is essential. This study systematically reviews existing research to assess dental students' awareness of HPV and its link to OPC.

A systematic review and meta-analysis were conducted following PRISMA guidelines. PubMed, ProQuest, and Web of Science databases were searched for studies published up to August 2023. The Newcastle-Ottawa Scale was used to evaluate study quality. A random effects model was applied to calculate pooled prevalence with 95% confidence intervals.

Sixteen studies, comprising 6,345 participants, were included. The pooled analysis showed that 69% of dental students had general knowledge of HPV (range: 56%–96.5%; 95% CI: 0.56–0.81), while 77% recognized its association with OPC (range: 18%–96.4%; 95% CI: 0.63–0.89). Significant heterogeneity was observed across studies (Q = 646.34, P < 0.001 for HPV; Q = 804.07, P < 0.001 for HPV-OPC).

Knowledge gaps among dental students may hinder prevention efforts. Standardized education in dental curricula is crucial to ensure future dentists are well-prepared to address HPV-related conditions and promote early detection in clinical practice.