# Case Report: Kyrieleis plaques in an unusual Behcet's disease uveitis

**Authors:** Jiani Li, Tantai Zhao, Xiaojian Guo, Yangyan Xiao

PMC · DOI: 10.3389/fmed.2025.1544319 · Frontiers in Medicine · 2025-05-22

## TL;DR

This case report describes a rare retinal finding in a patient with Behcet's disease uveitis.

## Contribution

It is the first reported case of Kyrieleis plaques in Behcet's disease uveitis.

## Key findings

- Kyrieleis plaques were observed in bilateral retinal arteries of a Behcet's disease patient.
- The plaques persisted despite immunosuppressive treatment for six months.
- The case suggests Kyrieleis plaques can occur in non-infectious uveitis like Behcet's disease.

## Abstract

Kyrieleis plaques are a rare retinal manifestation that has rarely been reported in Behcet's disease uveitis. We report the case of a 41-year-old man who presented with Behçet's disease uveitis combined with central serous chorioretinopathy. Laboratory studies showed positive for human leukocyte antigen B51. Polymerase chain reaction analysis of aqueous humor excluded infectious uveitis. Kyrieleis plaques were observed in the bilateral retinal arteries. These plaques persisted in both eyes after half a year of immunosuppressive treatments. Kyrieleis plaques are not limited to infectious uveitis; they can also be associated with Behçet's disease uveitis.

## Linked entities

- **Diseases:** uveitis (MONDO:0020283), central serous chorioretinopathy (MONDO:0018616)

## Full-text entities

- **Diseases:** Kyrieleis plaques (MESH:D003773), serous chorioretinopathy (MESH:D056833), Behcet's disease uveitis (MESH:D001528), infectious uveitis (MESH:D014605)

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC12137255/full.md

## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12137255/full.md

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Source: https://tomesphere.com/paper/PMC12137255