# Orbital inflammatory disease in a primarily black patient population

**Authors:** Gabriel Kabarriti, Ali Elsayed, Giannis A. Moustafa, Nickisa Hodgson

PMC · DOI: 10.3389/fopht.2025.1576929 · Frontiers in Ophthalmology · 2025-05-22

## TL;DR

This study examines orbital inflammatory disease in a primarily Black patient population, analyzing demographics, treatments, and outcomes.

## Contribution

The study provides insights into OID in an underrepresented Black population, highlighting treatment responses and disease characteristics.

## Key findings

- 85% of patients had successful outcomes with symptom resolution.
- Steroid-sparing therapy was needed for 12.8% of patients.
- Non-specific orbital inflammation and dacryoadenitis were the most common diagnoses.

## Abstract

The purpose of this study is to characterize orbital inflammatory disease (OID) in a primarily Black patient population, examining their demographics, presentations, workup, treatment, and outcome.

A retrospective study was performed from January 2005 to June 2022 at two academic institutions in Brooklyn, NY. Patients included met criteria for one of the following OID conditions: non-specific orbital inflammation; nonbacterial dacryoadenitis; Tolosa-Hunt; orbital myositis; definite, possible, or probable IgG4-related ophthalmic disease; and sclerosing orbital inflammation. Data reviewed included orbital inflammatory labs, imaging, pathology, and treatment. Treatment was considered successful if a patient had complete resolution of symptoms.

Thirty-nine patients met criteria for this study. 35.9% were diagnosed with dacryoadenitis, 28.2% with NSOI, 12.8% with myositis, 5.1% with possible IgG-ROD, 7.7% with probable IgG4-ROD, 7.7% with Tolosa Hunt, and 2.6% with sclerosing OI. 91% were started on steroids; 12.8% required transition to steroid-sparing therapy. 85% had a successful outcome with a resolution of symptoms.

This study characterizes OID in a Black patient population and compares it to prior studies done on OID. Research on underrepresented patient populations is needed to understand differences in disease presentation and improve patient outcomes.

## Linked entities

- **Diseases:** dacryoadenitis (MONDO:0004804), orbital myositis (MONDO:0004769)

## Full-text entities

- **Diseases:** ROD (OMIM:120970), myositis (MESH:D009220), inflammatory (MESH:D007249), orbital myositis (MESH:D055622), OID (MESH:D009916), sclerosing OI (MESH:D012598), IgG4 (MESH:D000077733), Tolosa Hunt (MESH:D020333), dacryoadenitis (MESH:D003607), IgG (MESH:D017099)
- **Chemicals:** steroid (MESH:D013256)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## References

21 references — full list in the complete paper: https://tomesphere.com/paper/PMC12137059/full.md

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Source: https://tomesphere.com/paper/PMC12137059