Editorial Note: How sex chromosomes get trapped into nonrecombination

Abstract
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Taxonomy
TopicsGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities · Sexual Differentiation and Disorders · Sperm and Testicular Function
This Primer [1] discusses a model presented in a Research Article by Jay et al. [2] published in the same issue of PLOS Biology.
This Editorial Note informs readers that the Research Article [2] (discussed in this Primer as reference 4) has been retracted [3].
The author notes that the processes initially reported in the retracted article and discussed in this Primer have individually also been reported in other studies, notably the role of inversions in establishing recombination suppression [4] and the sheltering of deleterious mutations [5], and continue to be debated.
The reference list from the paper itself. Each links out to its DOI / PubMed record.
- 1Käfer J. How sex chromosomes get trapped into nonrecombination. P Lo S Biol. 2022;20(7): e 3001718. doi: 10.1371/journal.pbio.3001718 35882230 PMC 9295974 · doi ↗ · pubmed ↗
- 2Jay P, Tezenas E, Véber A, Giraud T. Sheltering of deleterious mutations explains the stepwise extension of recombination suppression on sex chromosomes and other supergenes. P Lo S Biol. 2022;20(7): e 3001698. doi: 10.1371/journal.pbio.3001698 35853091 PMC 9295944 · doi ↗ · pubmed ↗
- 3The PLOS Biology Editors. Retraction: Sheltering of deleterious mutations explains the stepwise extension of recombination suppression on sex chromosomes and other supergenes. P Lo S Biol 2025;23(3): e 3003106. doi: 10.1371/journal.pbio.300310640146696 · doi ↗ · pubmed ↗
- 4Lenormand T, Roze D. Y recombination arrest and degeneration in the absence of sexual dimorphism. Science. 2022;375(6581):663–6. doi: 10.1126/science.abj 1813 35143289 · doi ↗ · pubmed ↗
- 5Nei M. Accumulation of nonfunctional genes on sheltered chromosomes. Am Nat. 1970;104(938):311–22. doi: 10.1086/282665 · doi ↗
