# History of Oral Mucosal Lesions in Oral Squamous Cell Carcinoma Patients

## TL;DR

This study found that about a third of oral cancer patients had a history of oral mucosal lesions, and those with prior dysplasia were more likely to be diagnosed during routine check-ups.

## Contribution

The study provides new insights into the relationship between prior mucosal lesions and the detection mode of oral squamous cell carcinoma.

## Key findings

- 32% of patients had a history of oral mucosal lesions before OSCC diagnosis.
- Heavy alcohol users were less likely to have prior mucosal lesions or dysplasia.
- Patients with prior dysplasia were more likely to be diagnosed during routine appointments.

## Abstract

To evaluate the occurrence of previous mucosal dysplasia in patients with oral squamous cell carcinoma (OSCC) and to charaterise patient profile, types of previous oral mucosal lesions, and care-seeking in relation to earlier mucosal findings.

Retrospective data of OSCC patients with a primary tumour were collected. The primary outcome variable was any history of oral mucosal findings; the secondary outcome variable was a history of previous oral mucosal dysplasia. The primary predictor variable was the mode of seeking treatment. Patient and tumour-related variables were compared between patients with and without anamnestic mucosal changes or findings.

A total of 528 patients were included in the study. Of these patients, 169 (32.0%) had a history of an oral mucosal lesion. Oral mucosal dysplasia was detected in 34 patients (6.4%) before the OSCC diagnosis. Patients who had a history of heavy alcohol use were less likely to have a history of any mucosal lesions or dysplasia (adjusted odds ratio [aOR] 0.350, 95% confidence interval [CI] 0.215-0.571, p < 0.001 and aOR 0.235, 95% CI 0.070-0.795, p = 0.020). Tumours were detected more often in conjunction with routine appointments in patients with a history of any mucosal lesions (aOR 2.671, 95% CI 1.704-4.187, p < 0.001) and in those with previously detected dysplasia (aOR 6.195, 95% CI 3.004-12.774, p < 0.001).

The results emphasise the importance of careful examination and close follow-up of findings in the oral mucosa.