# Comparison of the Effects of Blood Cardioplegia and Del Nido Cardioplegia on Postoperative Intensive Care Needs, Drainage, and Renal Functions in Patients Undergoing Isolated Coronary Artery Bypass

## TL;DR

This study compares two cardioplegia methods to see which is better for post-surgery recovery, focusing on intensive care needs, drainage, and kidney function.

## Contribution

The study provides a comparative analysis of Del Nido and blood cardioplegia effects on postoperative outcomes in coronary artery bypass patients.

## Key findings

- Del Nido cardioplegia was associated with longer aortic cross-clamping duration.
- Higher noradrenaline doses were needed in the Del Nido group.
- Del Nido cardioplegia showed a significant increase in acute kidney injury.

## Abstract

A variety of cardioplegia techniques with different components are
implemented to ensure myocardial protection, in addition to keeping the
operationa field immobile and free of blood during cardiac surgery. The
implemented cardioplegia has unwanted negative effects on other end organs.
In this study, our aim was to compare the effects of Del Nido cardioplegia
and blood cardioplegia solutions on postoperative intensive care duration,
drainage, and renal functions for patients undergoing cardiopulmonary bypass
and bypass graft operations.

Selections were made from patients undergoing elective bypass graft
operations in our clinic from January 1, 2022 to December 31, 2023. Patients
were randomly selected, retrospectively assessed, and divided into two
groups — De Nido group (Group 1) and blood cardioplegia group (Group 2).
Comparisons were made between these groups in terms of intensive care
duration, drainage, and renal functions.

The study included 120 patients. The Del Nido cardioplegia group included 60
patients, with 60 patients in the blood cardioplegia group. Comparisons
between the groups found that the aortic cross-clamping duration was
significantly high in Group 1 (P = 0.014). The
noradrenaline dose given to Group 1 was high (P = 0.004).
In terms of renal injury, significant degree of elevation was present in
Group 1 (P = 0.027). The longer aortic cross-clamping
duration in Group 1 may be assessed as a determinant factor for
noradrenaline dose and acute kidney injury.

This study concluded that it willbe appropriate to choose the cardioplegia
method by performing broader meta-analysis studies and minimizing limiting
factors.