# Enhanced Drug Loading Capacity Using the Dual Metformine–Dexketoprofren Salt on Nanoapatite Materials

## TL;DR

This paper explores using nanoapatite materials to improve drug delivery by combining metformin and dexketoprofen into a single salt, significantly boosting drug solubility and loading capacity.

## Contribution

The novel dual metformin–dexketoprofren salt on nanoapatite enhances drug loading and solubility, offering a new strategy for drug delivery.

## Key findings

- The novel salt increases dexketoprofen loading in nanoapatite by 50-fold compared to the native drug.
- The salt improves solubility to 567 mg/mL at pH 6.8 and 168 mg/mL at pH 1.2.
- Nanoapatite materials show enhanced stability and bioavailability of the pharmaceutical compounds.

## Abstract

Both apatite nanoparticles
and multicomponent pharmaceutical materials
have proved the ability to significantly improve the bioavailability
of different drugs using different strategies. Herein, the use of
nanoapatite is proposed as a promising vehicle for advanced drug delivery
of multicomponent pharmaceutical materials. To this purpose, the full
synthesis and comprehensive characterization of apatite nanoparticles
and the molecular pharmaceutical salt metformin–dexketoprofen
are reported, paying special attention to the improvements regarding
solubility and stability of the novel materials compared to the parent
active pharmaceutical ingredients, as well as the drug loading capacity
enhancement achieved in nanoapatites. Our results evidence the potential
of the presented novel strategy, enhancing the dexketoprofen-loading
a remarkable 50-fold when compared to native drug, thanks to the improvement
of solubility achieved via salt-formation (567 and 168 mg/mL at pH
6.8 and 1.2, respectively), thus expecting improved therapeutic outcomes.