# A Case Series and Literature Review of Angiosarcoma With Malignant Effusion—A Challenging Cytologic Diagnosis With Dire Prognostic Implications

## TL;DR

This paper discusses the challenges of diagnosing angiosarcoma with malignant effusion, highlighting its similarity to other cancers and poor prognosis.

## Contribution

The paper presents a case series and literature review to improve diagnostic approaches for angiosarcoma with malignant effusion.

## Key findings

- Angiosarcoma with malignant effusion is difficult to distinguish from metastatic adenocarcinoma.
- Immunocytochemical markers and clinical context are crucial for accurate diagnosis.
- The condition has a poor prognosis, emphasizing the need for early and accurate detection.

## Abstract

Angiosarcoma with malignant effusion is an uncommon yet clinically aggressive presentation, which poses as a diagnostic pitfall with its overlapping cytomorphologic features with metastatic adenocarcinoma. In this article, two cases reported in the literature were reviewed for cytology, immunocytochemistry, and clinical course. Key clinical hints, useful cytological features, and immunocytochemical markers in the diagnostic approach of this entity are presented.