# Whole-genome sequencing and comparative genomic analysis of Irpex lacteus isolated from the female reproductive tract

## TL;DR

A new strain of the fungus Irpex lacteus was found in a human patient and its genome was sequenced, revealing adaptations and potential risks.

## Contribution

A novel I. lacteus strain from a human host was isolated and genomically characterized for the first time.

## Key findings

- The human-derived I. lacteus strain shows significant genomic variation compared to other strains.
- Environmental adaptation has influenced specific functional traits in I. lacteus strains.
- Potential virulence factors were identified, suggesting a risk of opportunistic infections.

## Abstract

Irpex lacteus is a fungus typically found on angiosperm branches and trunks. Here, we report the isolation of a novel strain of I. lacteus from the cervix uteri of a female patient diagnosed with endometriosis and COVID-19 at Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Using whole-genome sequencing, we generated a high-quality draft genome for this human-derived strain. Comparative genomic analysis revealed significant variations amongst I. lacteus strains colonizing distinct environments. Functional annotations indicated that environmental adaptation has influenced specific functional traits in the strains. Moreover, potential virulence factors were identified, implying a risk of opportunistic infections associated with I. lacteus. This study elucidates the adaptive characteristics of I. lacteus across ecological niches and provides genomic insights into its opportunistic colonization.