# Single arm meta-analysis of the J-Valve system for aortic regurgitation in Chinese populations

## TL;DR

This study finds that the J-Valve system is effective for treating aortic regurgitation in Chinese patients, but complications remain a concern.

## Contribution

A meta-analysis of J-Valve outcomes in Chinese populations, highlighting efficacy and safety with specific complication rates.

## Key findings

- The J-Valve system achieved a 96% procedural success rate in treating aortic regurgitation.
- Complication rates, including a 22% incidence of other complications, remain notable despite high success rates.
- Short-term mortality rates were low, with in-hospital and 30-day mortality rates at 3%.

## Abstract

This meta-analysis aimed to evaluate the efficacy and safety of J-valve in patients with Aortic regurgitation (AR).

PubMed, Embase, the Cochrane Library, and Web of Science databases were searched from inception to November 2024. Primary outcome included Procedural Success, and secondary outcome included In-Hospital Mortality, 30-Day Mortality, One-Year All-Cause Mortality, Stroke Incidence and Complications. The risk of bias was assessed by subgroup analysis, sensitivity analysis, and publication bias, including funnel plot, Egger's test, and Begg's test.

A total of 9 studies involving 552 patients were included in this meta-analysis. The results indicated a surgical success rate of 96% (95% CI: 0.94–0.99). The in-hospital mortality rate was 3% (95% CI: 0.01–0.04), the 30-day mortality rate was 3% (95% CI: 0.01–0.05), and the 1-year all-cause mortality rate was 6% (95% CI: 0.04–0.08). Additionally, the incidence of stroke was 2% (95% CI: 0.01–0.03), and the incidence of other complications was 22% (95% CI: 0.16–0.28).

This meta-analysis indicates that the J-Valve prosthesis exhibits favorable short-term efficacy in patients with severe aortic regurgitation (AR); however, a significant incidence of complications persists. A thorough risk assessment is crucial when determining the appropriate treatment strategy. Furthermore, postoperative follow-up duration should be extended to monitor patient outcomes effectively.

https://www.crd.york.ac.uk/PROSPERO/view/CRD42024552406, identifier CRD42024552406.