[Corrigendum] Smoothened antagonist GDC-0449 (Vismodegib) inhibits proliferation and triggers apoptosis in colon cancer cell lines
Chuanqing Wu, Shaobo Hu, Ji Cheng, Guobin Wang, Kaixiong Tao
Abstract
Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.
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TopicsHedgehog Signaling Pathway Studies · Cancer Mechanisms and Therapy · Advanced Breast Cancer Therapies
Exp Ther Med 13:2529–2536, 2017; DOI: 10.3892/etm.2017.4282
Subsequently to the publication of the above article, an interested reader drew to the authors’ attention that the control western blots shown in Figs. 1C and 4C were strikingly similar (although it was conceivable that these blots may have been included as intended in these figures); however, the blots included in Fig. 1C to show the results of the Gli/Caco-2 experiments were also apparently the same as those shown in Fig. 4C for the Bcl-2/Caco-2 experiments, suggesting that, at least in the latter case, the same data had been used to show the results from experiments performed under different conditions.
After having consulted their original data, the authors realized that these figures had been assembled incorrectly, although, due to the time that has elapsed since this paper was published, they no longer had access to their original data. The authors, however, were able to repeat these experiments, and the revised versions of Figs. 1 and 4, containing replacement data for Figs. 1C and 4C, are shown on the next two pages. Note that the results obtained from the repeated experiments were broadly the same as the original results, and the revised data shown for these figures do not affect the overall conclusions reported in the paper. All the authors agree with the publication of this corrigendum; furthermore, they apologize to the Editor of Experimental and Therapeutic Medicine and to the readership for any inconvenience caused.