# Feasibility of Point-of-Care Urine Self-Testing to Measure Tenofovir Adherence and Predict Viral Suppression

**Authors:** Renata Buccheri, Matthew A Spinelli, Megan J Heise, David V Glidden, Kevin Sassaman, Tyler Martinson, Hannah R Schmidt, Alexa B D’Angelo, Dustin T Duncan, Keith J Horvath, Sabina Hirshfield, Renessa S Williams, Mallory O Johnson, Christian Grov, Adam Carrico, Monica Gandhi

PMC · DOI: 10.1093/ofid/ofaf300 · Open Forum Infectious Diseases · 2025-05-17

## TL;DR

This study shows that at-home urine testing can effectively monitor tenofovir adherence and predict viral suppression in patients.

## Contribution

The first demonstration of using a point-of-care urine assay for at-home tenofovir adherence monitoring.

## Key findings

- Undetectable tenofovir is strongly linked to lower viral suppression.
- The approach offers a streamlined method for adherence monitoring between viral load tests.

## Abstract

This study is the first to demonstrate the feasibility of at-home adherence monitoring using a point-of-care urine assay for tenofovir (TFV). Undetectable TFV is strongly associated with lower viral suppression (odds ratio, 0.19, 95% CI, 0.10–0.34; P < .001), supporting a streamlined, effective approach for monitoring adherence between viral load assessments.

## Linked entities

- **Chemicals:** tenofovir (PubChem CID 464205)

## Full-text entities

- **Chemicals:** TFV (MESH:D000068698)

## Full text

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## References

12 references — full list in the complete paper: https://tomesphere.com/paper/PMC12131155/full.md

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Source: https://tomesphere.com/paper/PMC12131155