# Relação entre o Escore Prognóstico de Nápoles e a Doença do Enxerto de Veia Safena após Cirurgia de Revascularização do Miocárdio

**Authors:** Ahmet Karaduman, Cemalettin Yılmaz, Muhammet Mucahit Tiryaki, İsmail Balaban, Mustafa Ferhat Keten, Tuba Unkun, Servet İzci, Suleyman Çağan Efe, Elnur Alizade, Ahmet Karaduman, Cemalettin Yılmaz, Muhammet Mucahit Tiryaki, İsmail Balaban, Mustafa Ferhat Keten, Tuba Unkun, Servet İzci, Suleyman Çağan Efe, Elnur Alizade

PMC · DOI: 10.36660/abc.20240519 · Arquivos Brasileiros de Cardiologia · 2025-05-15

## TL;DR

A new score called the Naples Prognostic Score (NPS) is linked to vein graft disease after heart surgery, suggesting it could help predict and monitor this complication.

## Contribution

The study introduces the NPS as a novel predictor of saphenous vein graft disease after coronary artery bypass surgery.

## Key findings

- The Naples Prognostic Score (NPS) was significantly higher in patients with degenerative saphenous vein grafts.
- NPS emerged as a significant predictor of saphenous vein graft disease, along with hypertension, chronic kidney disease, and other factors.
- Patients with elevated NPS after surgery should be monitored closely for vein graft disease.

## Abstract

A permeabilidade do enxerto de veia safena (EVS) continua sendo um desafio em casos de doença arterial coronária após cirurgia de revascularização do miocárdio (CRM). O escore prognóstico de Nápoles (NPS) constitui um novo sistema de pontuação projetado para avaliar tanto o estado nutricional quanto a inflamação.

Nosso estudo teve como objetivo explorar a associação entre NPS e doença do EVS em pacientes com histórico prévio de CRM.

Foram revisados um total de 702 pacientes submetidos à CRM e à angiografia coronáriaretrospectivamente. A doença do EVS foi definida como a presença de estenose ≥50% em pelo menos um EVS. Os pacientes foram categorizados em dois grupos com base na presença ou ausência de doença do EVS. Valores de p<0,05 foram aceitos como estatisticamente significativos.

A população do estudo consistiu em 702 pacientes, com 269 (38,3%) apresentando EVSs degenerativos e 433 (61,7%) sem EVSs degenerativos. O NPS foi maior no grupo com degeneração da veia safena e surgiu como um preditor significativo de doença do EVS (OR: 1,596, IC 95%: 1,198-2,125, p=0,001). Além disso, hipertensão (OR: 2,344, IC 95%: 1,137-4,833, p=0,02), doença renal crônica (OR: 3,337, IC 95%: 1,554-7,168, p=0,002), uso de estatina (OR: 0,434, IC 95%: 0,239-0,789, p=0,006), intervalo de tempo desde a CRM (OR: 1,138, IC 95%: 1,213-1,432, p<0,001) e número de EVSs (OR: 2,708, IC 95%: 1,902-3,855, p<0,001) foram preditores significativos da doença do EVS.

O NPS, uma ferramenta útil para avaliar inflamação e estado nutricional, pode fornecer informações valiosas sobre a permeabilidade de EVSs após cirurgia de CRM. Pacientes com NPS elevado após CRM devem passar por monitoramento cuidadoso para o desenvolvimento de doença de EVS.

Figura Central:Relação entre o Escore Prognóstico de Nápoles e a Doença do Enxerto de Veia Safena após Cirurgia de Revascularização do Miocárdio

Saphenous vein graft (SVG) patency remains a challenge in cases of coronary artery disease following coronary artery bypass grafting (CABG) surgery. The Naples prognostic score (NPS) constitutes a novel scoring system designed to assess both nutritional status and inflammation.

Our study aimed to explore the association between the NPS and SVG disease in patients with a previous history of CABG surgery.

A total of 702 patients who had undergone CABG surgery and underwent coronary angiography were reviewed retrospectively. SVG disease was defined as the presence of ≥50% stenosis in at least one SVG. Patients were categorized into two groups based on the presence or absence of SVG disease. Values of p<0.05 were accepted as statistically significant.

The study population consisted of 702 patients, with 269 (38.3%) having degenerative SVGs and 433 (61.7%) without degenerative SVGs. The NPS was higher in the group with saphenous vein degeneration and emerged as a significant predictor of SVG disease (OR: 1.596, 95% CI: 1.198-2.125, p=0.001). Additionally, hypertension (OR: 2.344, 95% CI: 1.137-4.833, p=0.02), chronic kidney disease (OR: 3.337, 95% CI: 1.554-7.168, p=0.002), statin usage (OR: 0.434, 95% CI: 0.239-0.789, p=0.006), time interval since CABG (OR: 1.138, 95% CI: 1.213-1.432, p<0.001), and number of SVGs (OR: 2.708, 95% CI: 1.902-3.855, p<0.001) were significant predictors of SVG disease.

The NPS, a useful tool for assessing inflammation and nutritional status, could provide valuable information about the patency of SVGs following CABG surgery. Patients with elevated NPS after CABG should undergo careful monitoring for the development of SVG disease.

Central Illustration:Relationship Between the Naples Prognostic Score and Saphenous Vein Graft Disease after Coronary Artery Bypass Grafting Surgery

## Linked entities

- **Diseases:** coronary artery disease (MONDO:0005010), chronic kidney disease (MONDO:0005300)

## Full-text entities

- **Diseases:** inflammation (MESH:D007249), chronic kidney disease (MESH:D051436), saphenous vein degeneration (MESH:D009410), degenerative SVGs (MESH:D019636), SVG disease (MESH:D055589), stenosis (MESH:D003251), coronary artery disease (MESH:D003324), hypertension (MESH:D006973)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

41 references — full list in the complete paper: https://tomesphere.com/paper/PMC12129478/full.md

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Source: https://tomesphere.com/paper/PMC12129478