# Valor Prognóstico da Taquicardia Ventricular não Sustentada na Miocardiopatia Hipertrófica em Coorte Brasileira: Comparação com Literatura Mundial

**Authors:** Diego Araújo Silva, Edmundo Arteaga-Fernandez, Viviane Tiemi Hotta, Charles Mady, Barbara Ianni, Felix Ramires, Luciano Nastari, Fábio Fernandes, Juliano Novaes Cardoso, Diego Araújo Silva, Edmundo Arteaga-Fernandez, Viviane Tiemi Hotta, Charles Mady, Barbara Ianni, Felix Ramires, Luciano Nastari, Fábio Fernandes, Juliano Novaes Cardoso

PMC · DOI: 10.36660/abc.20240399 · Arquivos Brasileiros de Cardiologia · 2025-05-13

## TL;DR

This study finds that nonsustained ventricular tachycardia in Brazilian patients with hypertrophic cardiomyopathy is linked to higher mortality over 15 years.

## Contribution

The study provides new insights into the prognostic value of nonsustained ventricular tachycardia in a Brazilian cohort with hypertrophic cardiomyopathy.

## Key findings

- Nonsustained ventricular tachycardia was present in 10% of patients with hypertrophic cardiomyopathy.
- Long-lasting and fast nonsustained ventricular tachycardia was rare, occurring in only 1.4% of patients.
- Patients with nonsustained ventricular tachycardia had higher 15-year all-cause mortality (26.3%) compared to those without (15.9%).

## Abstract

Na miocardiopatia hipertrófica (MCH), é conhecida a associação entre a taquicardia ventricular não sustentada (TVNS) e o risco de morte súbita.

Avaliar a incidência de TVNS pelo Holter 24 h em pacientes com MCH em coorte brasileira e correlacionar com suas características e evolução.

No presente estudo retrospectivo de pacientes com MCH, avaliamos pelo Holter 24 h a presença de TVNS longas e rápidas (≥ 10 batimentos e frequência ≥ 130 bpm) ou a presença de pelo menos 3 episódios de TVNS com ≥ 3 batimentos e frequência ≥ 120 bpm. As variáveis contínuas foram apresentadas em médias aritméticas e desvio padrão e as variáveis categóricas em frequências absolutas e relativas. Foi considerado significativo p < 0,05.

Incluímos 763 pacientes, 53,5% do sexo masculino. A idade média foi de 52,6 anos ± 16,7. A presença de TVNS foi evidenciada em 10% (76 pacientes). Destes, apenas 11 (1,4%) apresentaram TVNS ≥ 10 batimentos e frequência ≥ 130 bpm. Não houve diferença na relação da TVNS com sexo, septo > 30 mm, idade ≥ 40 anos, dose de betabloqueador e presença de fibrilação atrial. No grupo com TVNS a mortalidade por todas as causas ao longo de 15 anos foi observada em 26,3% versus 15,9% no grupo sem TVNS (p = 0,021).

A presença de TVNS no Holter 24 h ocorreu em 10 % dos pacientes. As TVNS longas e rápidas foram raras. A presença de TVNS foi associada à maior mortalidade geral ao longo do seguimento.

Figura Central:Valor Prognóstico da Taquicardia Ventricular não Sustentada na Miocardiopatia Hipertrófica em Coorte Brasileira: Comparação com Literatura MundialValor prognóstico da taquicardia ventricular não sustentada na miocardiopatia hipertrófica em coorte brasileira. FC: frequência cardíaca; MCH: miocardiopatia hipertrófica; TVNS: taquicardia ventricular não sustentada.

Valor prognóstico da taquicardia ventricular não sustentada na miocardiopatia hipertrófica em coorte brasileira. FC: frequência cardíaca; MCH: miocardiopatia hipertrófica; TVNS: taquicardia ventricular não sustentada.

In hypertrophic cardiomyopathy (HCM), there is a well-known association between nonsustained ventricular tachycardia (NSVT) and the risk of sudden death.

To assess the incidence of NSVT using 24-hour Holter monitoring in patients with HCM in a Brazilian cohort and correlate it with its characteristics and progression.

This retrospective study of patients with HCM used 24-hour Holter monitoring to assess the presence of long-lasting, fast NSVT (≥ 10 beats and heart rate ≥ 130 bpm) or the presence of at least 3 episodes of NSVT with ≥ 3 beats and heart rate ≥ 120 bpm. Continuous variables were shown as arithmetic means and standard deviations, and categorical variables were shown as absolute and relative frequencies. P < 0.05 was considered significant.

We included 763 patients, 53.5% of whom were male. Their mean age was 52.6 years ± 16.7. NSVT was found in 10% (76 patients). Only 11 (1.4%) of them had NSVT with ≥ 10 beats and heart rate ≥ 130 bpm. There was no difference in the relationship between NSVT and sex, septum > 30 mm, age ≥ 40 years, betablocker dose, and presence of atrial fibrillation. In the group with NSVT, 15-year all-cause mortality was observed in 26.3%, compared to 15.9% in the group without NSVT (p = 0.021).

The presence of NSVT on 24-hour Holter monitoring occurred in 10% of patients. Long-lasting, fast NSVT was rare. The presence of NSVT was associated with higher overall mortality during follow-up.

Central Illustration:Prognostic Value of Nonsustained Ventricular Tachycardia in Hypertrophic Cardiomyopathy in a Brazilian Cohort: Comparison with World LiteraturePrognostic value of nonsustained ventricular tachycardia in hypertrophic cardiomyopathy in a Brazilian cohort. HCM: hypertrophic cardiomyopathy; HR: heart rate; NSVT: nonsustained ventricular tachycardia.

Prognostic value of nonsustained ventricular tachycardia in hypertrophic cardiomyopathy in a Brazilian cohort. HCM: hypertrophic cardiomyopathy; HR: heart rate; NSVT: nonsustained ventricular tachycardia.

## Linked entities

- **Diseases:** hypertrophic cardiomyopathy (MONDO:0005045)

## Full-text entities

- **Diseases:** NSVT (MESH:D017180), sudden death (MESH:D003645), HCM (MESH:D002312), atrial fibrillation (MESH:D001281)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

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## References

25 references — full list in the complete paper: https://tomesphere.com/paper/PMC12129476/full.md

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Source: https://tomesphere.com/paper/PMC12129476