# Crimean-Congo hemorrhagic fever with severe bradycardia treated with Theophylline

**Authors:** Murat Aydın, Nurten Nur Aydın

PMC · DOI: 10.1590/0037-8682-0416-2024 · Revista da Sociedade Brasileira de Medicina Tropical · 2025-06-02

## TL;DR

A 30-year-old man with Crimean-Congo hemorrhagic fever developed severe bradycardia, which was successfully treated with theophylline.

## Contribution

This case report demonstrates the successful use of theophylline to treat severe bradycardia in CCHF.

## Key findings

- Severe bradycardia is a rare but serious complication of CCHF.
- Theophylline treatment improved cardiac function in a CCHF patient with bradycardia.
- Pharmacological intervention can be effective in managing cardiac complications of CCHF.

## Abstract

Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne viral hemorrhagic fever caused by Nairovirus and characterized by fever, myalgia, arthralgia, and hemorrhagic manifestations. Severe bradycardia is a rare complication of the disease. We present a 30-year-old male patient with CCHF who developed severe bradycardia, which was successfully treated with intravenous and oral theophylline. This case highlights the need to recognize cardiac complications in CCHF and highlights the role of pharmacological interventions in improving patient outcomes.

## Linked entities

- **Chemicals:** Theophylline (PubChem CID 2153)
- **Diseases:** Crimean-Congo hemorrhagic fever (MONDO:0020501)

## Full-text entities

- **Diseases:** arthralgia (MESH:D018771), bradycardia (MESH:D001919), myalgia (MESH:D063806), hemorrhagic (MESH:D006470), hemorrhagic fever (MESH:D006480), CCHF (MESH:D006479), fever (MESH:D005334), cardiac complications (MESH:D006331)
- **Chemicals:** Theophylline (MESH:D013806)
- **Species:** Homo sapiens (human, species) [taxon 9606], Orthonairovirus (genus) [taxon 1980517]

## Full text

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## Figures

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## References

11 references — full list in the complete paper: https://tomesphere.com/paper/PMC12129135/full.md

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Source: https://tomesphere.com/paper/PMC12129135